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VIP

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Vasoactive Intestinal (VIP) is a 28-amino acid neuro supplied in lyophilized form for in vitro and in vivo research applications. This research-grade enables investigation of VPAC receptor signaling, neuroimmune interactions, smooth muscle regulation, and circadian rhythm mechanisms.
CAS #: 37221-79-7

Purity ≥ 99% CAS 37221-79-7 Third party tested

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COA Testing Parameters

Identity Verification – HPLC and Mass Spectrometry confirm molecular structure
Purity Analysis – HPLC quantification, typically ≥98%
Concentration Accuracy – Verified dosing levels
Molecular Weight – Mass spectrometry confirmation
Endotoxin Screening – LAL assay, <1.0 EU/mg
pH Testing – Solution stability validation
Sterility – Microbial contamination screening
Heavy Metals – Lead, mercury, cadmium analysis
Residual Solvents – Organic solvent detection
Moisture Content – Karl Fischer titration
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Overview

VIP

VIP (Vasoactive Intestinal )

Chemical Specifications:

Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
Molecular Formula: C₁₄₇H₂₃₇N₄₃O₄₂S
Molecular Weight: 3326.77 Da
Structure: 28 amino acids with C-terminal amidation
CAS Number: 37221-79-7
Form: Sterile lyophilized white to off-white powder

Molecular Mechanism:

Receptor Targets:

VPAC1 Receptor (VIP/PACAP receptor type 1) – Gs-coupled GPCR, widely distributed
VPAC2 Receptor (VIP/PACAP receptor type 2) – Gs-coupled GPCR, tissue-specific expression
Weak PAC1 binding – Lower affinity than PACAP

Signaling Pathways:

cAMP/PKA Activation: Primary pathway through Gs coupling
Vasodilation: Smooth muscle relaxation via cAMP-dependent mechanisms
Immunomodulation: Anti-inflammatory cytokine regulation (↓TNF-α, ↑IL-10)
Neuroprotection: BDNF upregulation, anti-apoptotic signaling

Research Context:

VIP was discovered in 1970 as a potent vasodilator . Subsequent research revealed its extensive distribution and pleiotropic functions across multiple organ systems. VIP’s anti-inflammatory and immunomodulatory properties have driven research in autoimmune disease, sepsis, and neuroinflammation models. Its role in circadian rhythm regulation (master clock synchronization in SCN) makes it valuable for chronobiology research.