MTP-31 (Elamipretide)
is a mitochondrial-targeting aromatic-cationic tetrapeptide supplied in lyophilized form for laboratory research applications. This cell-permeable peptide selectively concentrates in mitochondrial inner membranes through electrostatic interactions with cardiolipin, making it a valuable tool for investigating mitochondrial dysfunction, oxidative stress, and bioenergetic failure in various disease models.
Chemical Specifications:
- Sequence: D-Arg-Dmt-Lys-Phe-NHâ‚‚ (where Dmt = 2′,6′-dimethyltyrosine)
- Molecular Formula: C₃₂H₅₂N₈O₅
- Molecular Weight: 640.81 Da
- CAS Number: 736992-21-5
- Alternative Names: Elamipretide, Bendavia, MTP-131
- Form: Sterile lyophilized white powder
Molecular Mechanism:
Mitochondrial Targeting Strategy:
- Cardiolipin Binding: MTP-31 selectively binds to cardiolipin, a phospholipid exclusively located in mitochondrial inner membrane
- Membrane Stabilization: Prevents cardiolipin peroxidation and maintains cristae structure
- ROS Scavenging: Aromatic dimethyltyrosine residue provides electron-donating capacity
- Bioenergetic Optimization: Enhances electron transport chain efficiency, reduces proton leak
Research Applications:
- Cardiovascular Research: Ischemia-reperfusion injury models, heart failure pathophysiology, myocardial infarction protection studies
- Neurodegeneration Models: Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, stroke research
- Mitochondrial Biology: Cristae morphology studies, cardiolipin biochemistry, mitochondrial membrane potential assays
- Aging Research: Age-related mitochondrial decline, sarcopenia, skeletal muscle dysfunction
- Renal Protection Studies: Acute kidney injury, chronic kidney disease progression models
- Metabolic Research: Insulin resistance, metabolic syndrome, obesity-related mitochondrial dysfunction





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