MTP-31 (SS-31) 50mg
MTP-31 (SS-31) 50mg - Image 2

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MTP-31 (SS-31) 50mg

SKU SS-31-VAR

Original price was: $228.99.Current price is: $184.99.

MTP-31 is a cell-permeable selectively concentrates in mitochondrial inner membranes through electrostatic interactions with cardiolipin, making it a valuable tool for investigating mitochondrial dysfunction, oxidative stress, and bioenergetic failure in various disease models.
CAS #: 736992-21-5

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Testing & Quality Assurance

Testing & Quality Assurance

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Complete Batch Testing

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COA Testing Parameters

  • Identity Verification – HPLC and Mass Spectrometry confirm molecular structure
  • Purity Analysis – HPLC quantification, typically ≥98%
  • Concentration Accuracy – Verified dosing levels
  • Molecular Weight – Mass spectrometry confirmation
  • Endotoxin Screening – LAL assay, <1.0 EU/mg
  • pH Testing – Solution stability validation
  • Sterility – Microbial contamination screening
  • Heavy Metals – Lead, mercury, cadmium analysis
  • Residual Solvents – Organic solvent detection
  • Moisture Content – Karl Fischer titration
  • Physical Inspection – Color, clarity, appearance
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The products offered by Premier Bio Labs are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
 

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Description

MTP-31 (Elamipretide)

is a mitochondrial-targeting aromatic-cationic tetra supplied in lyophilized form for laboratory research applications. This cell-permeable selectively concentrates in mitochondrial inner membranes through electrostatic interactions with cardiolipin, making it a valuable tool for investigating mitochondrial dysfunction, oxidative stress, and bioenergetic failure in various disease models.

Chemical Specifications:

  • Sequence: D-Arg-Dmt-Lys-Phe-NH₂ (where Dmt = 2′,6′-dimethyltyrosine)
  • Molecular Formula: C₃₂H₅₂N₈O₅
  • Molecular Weight: 640.81 Da
  • CAS Number: 736992-21-5
  • Alternative Names: Elamipretide, Bendavia, MTP-131
  • Form: Sterile lyophilized white powder

Molecular Mechanism:

Mitochondrial Targeting Strategy:

  • Cardiolipin Binding: MTP-31 selectively binds to cardiolipin, a phospholipid exclusively located in mitochondrial inner membrane
  • Membrane Stabilization: Prevents cardiolipin peroxidation and maintains cristae structure
  • ROS Scavenging: Aromatic dimethyltyrosine residue provides electron-donating capacity
  • Bioenergetic Optimization: Enhances electron transport chain efficiency, reduces proton leak

Research Applications:

  • Cardiovascular Research: Ischemia-reperfusion injury models, heart failure pathophysiology, myocardial infarction protection studies
  • Neurodegeneration Models: Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, stroke research
  • Mitochondrial Biology: Cristae morphology studies, cardiolipin biochemistry, mitochondrial membrane potential assays
  • Aging Research: Age-related mitochondrial decline, sarcopenia, skeletal muscle dysfunction
  • Renal Protection Studies: Acute kidney injury, chronic kidney disease progression models
  • Metabolic Research: Insulin resistance, metabolic syndrome, obesity-related mitochondrial dysfunction

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