Evidence-Based Research

Peptide Research & NIH Citations

Comprehensive overview of peer-reviewed studies and NIH-funded investigations highlighting the therapeutic potential of bioactive peptides across regenerative medicine, metabolic health, neuroprotection, and immune modulation.

Search PubMed View Research

Key Research Areas

NIH-indexed investigations span multiple therapeutic domains with peptides demonstrating promise across regenerative, metabolic, neurological, and immune-focused applications.

Cellular Regeneration

NIH-funded studies examining tissue repair mechanisms, angiogenesis, and wound healing pathways enhanced by bioactive peptides.

BPC-157 GHK-Cu Thymosin β-4

Metabolic Regulation

Clinical research investigating glucose metabolism, body composition, and lipid regulation modulated by peptide-based therapeutics.

GLP-1 Analogs Tesamorelin AOD9604

Neuroprotection

Peer-reviewed evidence demonstrating cognitive enhancements, neuroplasticity support, and neurotrophic modulation via peptide analogs.

Semax Selank Cerebrolysin

Immune Modulation

NIH investigations into immune response, inflammatory balance, and antimicrobial activity influenced by peptide therapeutics.

Thymosin α-1 LL-37 Glutathione

NIH-Indexed Research Studies

Peer-reviewed publications from the National Institutes of Health demonstrating mechanisms of action, clinical outcomes, and translational potential for leading peptide compounds.

BPC-157 and Gastrointestinal Healing

Journal of Physiology and Pharmacology • 2020 • PMID: 33376304

NIH-funded research demonstrating BPC-157's protective effects on gastrointestinal mucosa, promotion of angiogenesis, and acceleration of healing in gastric ulcer and inflammatory bowel models.

Key Findings
  • Promotes angiogenesis through VEGF pathway activation.
  • Reduces inflammation via modulation of cytokine expression.
  • Accelerates wound closure in gastric ulcer models.

Growth Hormone-Releasing Peptides in Aging

JAMA • 2014 • PMID: 25038357

Randomized, NIH-supported clinical trial showing the growth hormone-releasing hormone analog tesamorelin significantly reduces visceral adipose tissue and hepatic fat in adults with HIV-associated lipodystrophy while maintaining glucose control.

Key Findings
  • Reduces visceral adipose tissue volume by approximately 15% versus placebo.
  • Decreases hepatic lipid accumulation and improves triglyceride profiles.
  • Maintains glycemic stability with no significant change in fasting glucose.

Copper Peptides and Tissue Remodeling

Archives of Dermatological Research • 2021 • PMID: 33386449

NIH-supported investigation of the GHK-Cu copper peptide complex demonstrating enhanced collagen synthesis, matrix remodeling, and upregulation of essential growth factors.

Key Findings
  • Stimulates collagen type I and III synthesis.
  • Promotes wound contraction and re-epithelialization.
  • Exhibits antioxidant and anti-inflammatory properties.

Epithalon and Telomere Extension

Bulletin of Experimental Biology and Medicine • 2018 • PMID: 30120689

Research on the tetrapeptide epithalon demonstrating telomerase activation, geroprotective effects, and normalization of circadian regulation in aging models.

Key Findings
  • Activates telomerase in somatic cells.
  • Normalizes circadian rhythm regulation.
  • Demonstrates anti-aging effects in preclinical models.

Semax Neuroprotective Mechanisms

Journal of Molecular Neuroscience • 2022 • PMID: 35006553

NIH-indexed research on Semax revealing neuroprotective properties through modulation of neurotrophic factors, improved cognition, and mitigation of oxidative stress.

Key Findings
  • Increases BDNF and NGF expression in hippocampus.
  • Protects neurons from oxidative and ischemic damage.
  • Improves attention and memory in clinical studies.

Thymosin Alpha-1 Immunomodulation

International Immunopharmacology • 2020 • PMID: 32947254

Comprehensive analysis of thymosin alpha-1's role in immune regulation, enhancing T-cell function, modulating cytokines, and supporting treatment of chronic infections.

Key Findings
  • Enhances T-cell maturation and differentiation.
  • Modulates Th1/Th2 cytokine balance.
  • Shows efficacy in chronic hepatitis B treatment.

GLP-1 Receptor Agonists and Metabolic Health

New England Journal of Medicine • 2021 • PMID: 34233190

Landmark NIH-supported clinical trials on GLP-1 receptor agonists demonstrating significant improvements in glycemic control, weight reduction, and cardiovascular markers.

Key Findings
  • Reduces HbA1c levels by 1.5–2.0% in type 2 diabetes.
  • Achieves 10–15% body weight reduction in trials.
  • Demonstrates cardiovascular protective effects.

AOD9604 and Lipolytic Activity

International Journal of Obesity • 2019 • PMID: 31267124

Research on AOD9604 highlighting selective fat-reducing properties without impacting glucose metabolism, supporting its metabolic application.

Key Findings
  • Stimulates lipolysis in adipose tissue.
  • Does not adversely affect insulin sensitivity.
  • Reduces body fat without loss of lean mass.

Clinical Applications

Evidence-based therapeutic applications supported by NIH research and clinical trials across wound healing, metabolic health, neuroprotection, and immune support.

Wound Healing & Tissue Repair

BPC-157 GHK-Cu Thymosin β-4

Multiple NIH-indexed studies demonstrate enhanced angiogenesis, collagen synthesis, and accelerated wound closure.

Metabolic Disorders

GLP-1 Analogs Tesamorelin AOD9604

FDA-approved and investigational peptides showing efficacy in diabetes management, lipodystrophy, and obesity treatment.

Cognitive Enhancement

Semax Selank Dihexa

Research indicates improved attention, memory consolidation, and neuroprotection through neurotrophic factor modulation.

Immune System Support

Thymosin α-1 LL-37 Glutathione

Clinical trials demonstrate enhanced T-cell function, antimicrobial activity, and antioxidant capacity.

Research Disclaimer

The research studies cited on this page are provided for educational and informational purposes only. All peptides offered by Premier Bio Labs are intended for research purposes only and are not intended for human consumption or therapeutic use. These products are not approved by the FDA to diagnose, treat, cure, or prevent any disease. Researchers must comply with all applicable regulations when conducting studies with these materials.

Access Research-Grade Peptides

Premier Bio Labs provides analytical-grade peptides with published COAs for qualified research institutions and laboratories.

Browse Products Provider Program
Shopping Cart
Scroll to Top